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Amphetamine is known to inhibit monoamine oxidase, whereas the ability of amphetamine and its metabolites to inhibit numerous P450 isozymes along with other enzymes hasn't been adequately elucidated. In vitro experiments with human microsomes reveal small inhibition of CYP2D6 by amphetamine and slight inhibition of CYP1A2, 2D6, and 3A4 by a number